Autophagy in the eye: from physiology to pathophysiology

Autophagy in the eye: from physiology to pathophysiology

Blog Article

Autophagy is a catabolic self-degradative pathway that promotes the degradation and recycling of intracellular material through the lysosomal compartment.Although first believed to function in conditions of nutritional stress, autophagy is emerging as a grace m801 critical cellular pathway, involved in a variety of physiological and pathophysiological processes.Autophagy dysregulation is associated with an increasing number of diseases, including ocular diseases.On one hand, mutations in autophagy-related genes have been linked to cataracts, glaucoma, and corneal dystrophy; on the other hand, alterations in autophagy and lysosomal pathways are a common finding in essentially all diseases of the eye.

Moreover, LC3-associated phagocytosis, a form of non-canonical autophagy, is critical in promoting visual cycle function.This review collects the latest understanding of autophagy in the context of fox 985-24-100 reservoir shock the eye.We will review and discuss the respective roles of autophagy in the physiology and/or pathophysiology of each of the ocular tissues, its diurnal/circadian variation, as well as its involvement in diseases of the eye.